РЕЗУЛЬТАТЫ ПРИМЕНЕНИЯ АДЕМЕТИОНИНА ПРИ ОБШИРНЫХ РЕЗЕКЦИЯХ ПЕЧЕНИ

Aim. To study adamethionin effect on liver failure course after extensive liver resection. Material and Methods . 538 patients after extensive liver resection were included into study. Adamethionin has been used in the main group (326 patients) postoperatively while in the control group (212 patients) hepatoprotective therapy was absent. Incidence and severity of liver failure as well as postoperative complications were analyzed. Results. Total incidence of post-resection liver failure was 23% (18.7% and 30.2% in the main and control groups respectively, p 0.05). Postoperative hospital-stay was 15 (12–28) days in the control group and 11 (9–19) days in the main group (p < 0.05). Conclusion. Liver failure is possible after extensive liver resections (over three segments). Ademetionin contributes to restoration of liver structure and function, reduces the incidence of liver failure and hospital-stay, provides faster recovery of residual liver parenchyma.