A DEP-based lab-on-a-chip system for the detection of multidrug resistance in K562 leukemia cells
2016 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2016(2016)
Abstract
This study presents a DEP-based lab-on-a-chip (LOC) system for label-free detection of multidrug resistant (MDR) K562 leukemia cells in a cell mixture, consisting of red blood cells (RBCs) and MDR-K562 cells, for the first time in the literature.The system consists of 2 consecutive DEP units, one for the depletion of RBCs and the other for capturing of MDR-K562 cells.RBCs are depleted by 60% in the first unit.In the second unit, MDR-K562 cell detection is performed with 100% selectivity at a flow rate of 10 μl/min and at 20 V pp in a cell mixture, containing less than 25% MDR-K562 cells.
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Key words
multidrug resistance,leukemia cells,dep-based,lab-on-a-chip
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