Efficient extraction and antioxidant activity of polyphenols from Antrodia cinnamomea
BMC Biotechnology(2022)
Abstract
Background Antrodia cinnamomea , a rare medicinal fungus, has been increasingly studied in recent years because of its abundant secondary metabolites which are beneficial to humans. However, there is a lack of research on its polyphenols which are of good research value due to their antioxidant, anti-inflammatory, hypoglycemic and other activities. Results In this study, the effects of different extraction conditions on the yield of its polyphenols were investigated. Deep-Eutectic Solvents composed of choline chloride and malonic acid had the best extraction efficiency, with the optimal extraction conditions being as follows: a solid–liquid ratio of 40 mg/mL, an extraction temperature of 55 °C, an extraction time of 70 min and a DES with 20% water content. Under these conditions, the extraction yield of polyphenols reached 22.09 mg/g which was about 2 times that of alcohol-based extraction (10.95 mg/g). In vitro antioxidant test results further showed that polyphenols from A. cinnamomea had strong antioxidant activities. When the concentration of polyphenols reached 0.1 mg/mL of polyphenols, the scavenging activity of free radical basically reached its maximum, with values of 94.10%, 83.34% and 95.42% for DPPH, ABTS + and ·OH scavenging. In this case, the corresponding IC 50 values were 0.01, 0.014 and 0.007 mg/mL, respectively. Conclusions This study lays the foundation for the efficient extraction and application of polyphenols from A. cinnamomea.
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Key words
Antrodia cinnamomea
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