Cardiopulmonary Profile Of Individuals With Intellectual Disabilities During Maximal Exercise: 1985 Board #246 May 31 3 30 PM - 5 00 PM

Individuals with intellectual disabilities (ID) often live a sedentary life and present with low fitness levels. Exercise intolerance has been shown in individuals with Down syndrome, but in individuals with non-syndromic ID, the parameters derived from cardiopulmonary exercise tests (CPET) relating to exercise intolerance have not yet been thoroughly investigated. PURPOSE: Our purpose was to assess potential differences in the maximal oxygen uptake and full cardiopulmonary profile during CPET in individuals with non-syndromic ID and healthy controls. METHODS: Participants performed a treadmill CPET using an incremental protocol until exhaustion. Differences between groups in peak heart rate (HRpeak), peak oxygen uptake (VO2peak), peak minute ventilation (VEpeak), peak CO2 expired (VCO2peak), oxygen uptake efficiency slope (OUES), relationship between VE and VCO2 (VE/VCO2 slope), relationship between VO2 and HR (O2 pulse), heart rate reserve (HRR), and peak respiratory exchange ratio (RERpeak) were tested with students t-test and Mann Whitney-U tests. RESULTS: Nine individuals with ID (4 male, 32.3 ± 7.7 yrs, 23.0 ± 8.7 kg/m2) and nine age and sex matched controls (24.3 ± 2.9 kg/m2) were included. Individuals with ID demonstrated significantly lower values (p<0.05) in all outcomes compared to controls, except for VE/ VCO2 slope (p=0.06) and RERpeak (p=0.34). CONCLUSION: Even with similar effort (RERpeak) between groups, individuals with non-syndromic ID had lower heart rate related parameters and altered integration of cardiovascular, muscular and respiratory function. This likely partially explains the lower exercise capacity compared to matched controls. This project has received funding from the Marie Curie International Outgoing Fellowship within the 7th European Community Framework Program under grant agreement No 625455-ID Physiology.Table: No title available.All data are presented as mean ± SD, unless otherwise noted. a median ± IQR b Mann-Whitney U test