Avaliação da adaptação de formas farmacêuticas em um hospital pediátrico de Manaus

ABSTRACT:Background: The pharmaceutical form adaptation of medicines for pediatric use is frequent inBrazilian hospitals due to the lack of suitable formulations for children. This practice has been definedas an unlicensed use. Objective: In the present study, a descriptive, quantitative and retrospective studycovering different aspects related to pharmaceutical adaptation was carried out in a pediatric hospital inManaus during the year of 2016. Methods: Through the data collection from the hospital records, thedifferent pharmacological classes and pharmaceutical forms used and produced, some aspects of goodhandling practices and the standard operating procedures applied in these formulations were evaluated.In addition, the consultation of the availability of ready-made formulations in the national market asalternatives to the hospital’s production process and the accomplishment of calculations to verify theprice comparison were carried out. Results: In this study, diuretics were the most modified medicines(15,4%). The most produced therapeutic agents were Potassium Chloride and the associationSpironolactone and Hydrochlorothiazide (21.2%). The ready liquid dosage forms of dexamethasone,potassium chloride, oseltamivir and midazolam were found in the search on the market. In addition, ithas been found that, in the comparison between the production process and the market purchase, theadaptation is financially advantageous, according to the calculations made. Conclusions: Therefore,it is concluded that the adaptation of pharmaceutical forms is a reality in the studied hospital andthe need to purchase the industrialized product or to adapt the pharmaceutical form must take intoaccount not only the financial aspect but also other aspects such as demand, availability in the Market,pharmacotechnical aspects, safety, effectiveness, among other points.