Выбор донора при аллогенной трансплантации гемопоэтических стволовых клеток
Russian Journal of Children Hematology and Oncology(2016)
Abstract
Selection of donor is the basis for success of allogeneic hematopoietic stem cell (HSC) transplantation (allo-HSCT). It needs to consider the individual characteristics of recipient and donor. The main of these are -disease, the HLA-matching, type of donor (related, unrelated), the source of HSC (BM, PBSC, umbilical cord blood). For haplo-HSCT particular importance are donor age below 30 years, male, NIMA incompatibility, NK-allo reactivity. Currently, for each patient, having indications for allo-HSCT, can be found allogeneic HSC donor. The following possibilities may be considered consequentially: a matched related donor; matched unrelated donor; partially matched unrelated donor (9/10 or 8/10); haploidentical donor; umbilical cord blood; matched sibling donor after in vitro fertilization – preimplantation genetic diagnosis.
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Key words
transplantation,donor,selection
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