Correction: γ-Tocotrienol but not γ-tocopherol blocks STAT3 cell signaling pathway through induction of protein-tyrosine phosphatase SHP-1 and sensitizes tumor cells to chemotherapeutic agents (Journal of Biological Chemistry (2010) 285 (33520-33528))

γ-Tocotrienol but Not γ-Tocopherol Blocks STAT3 Cell Signaling Pathway through Induction of Protein-tyrosine Phosphatase SHP-1 and Sensitizes Tumor Cells to Chemotherapeutic AgentsJournal of Biological ChemistryVol. 285Issue 43PreviewAlthough γ-tocotrienol (T3), a vitamin E isolated primarily from palm and rice bran oil, has been linked with anticancer activities, the mechanism of this action is poorly understood. In this study, we investigated whether γ-T3 can modulate the STAT3 cell signaling pathway, closely linked to inflammation and tumorigenesis. We found that γ-T3 but not γ-tocopherol, the most common saturated form of vitamin E, inhibited constitutive activation of STAT3 in a dose- and time-dependent manner, and this inhibition was not cell type-specific. Full-Text PDF Open Access VOLUME 285 (2010) PAGES 33520–33528 This article has been retracted by the publisher. An investigation at MD Anderson determined that the image of nuclei from U266 cells treated with γ-T3 from Fig. 1G had been reused in Fig. 1D of Yadav, V. R., Prasad, S., Kannappan, R., Ravindran, J., Chaturvedi, M. M., Vaahtera, L., Parkkinen, J., and Aggarwal, B. B. (2010) Cyclodextrin-complexed curcumin exhibits anti-inflammatory and antiproliferative activities superior to those of curcumin through higher cellular uptake. Biochem. Pharmacol. 80, 1021–1032; the reused image represents different experimental conditions.