ПИВАЛОИЛ-ЗАМЕЩЕННЫЕ 2-ПИРРОЛОНЫ ИНДУЦИРУЮТ ГИБЕЛЬ ГАСТРОИНТЕСТИНАЛЬНЫХ СТРОМАЛЬНЫХ ОПУХОЛЕЙ, РЕЗИСТЕНТНЫХ К ИМАТИНИБУ И ХИМИОПРЕПАРАТАМ

There are presented data illustrating sensitivity of gastrointestinal stromal tumors (GISTs) to certain chemotherapeutic agents (topoisomerase type II inhibitors, taxanes, vinca alkaloids) and pivaloyl-containing heterocyclic pyrroles (PCHPs). The chemotherapeutic drugs indicated above provided the cytotoxicity to IM-sensitive GIST cells. PCHPs were effective in both IM-sensitive, and resistant GISTs as well. Moreover PCHPs were also active against GISTs harboring the resistance to the chemotherapeutic agents indicated above. PCHPs-treated tumor cells underwent apoptosis due to the M-phase abnormalities and mitotic catastrophe.