171P An unwelcome guest: P. gingivalis intratumoral infection and immune evasion in gastric cancer

Periodontal disease (PD) is an inflammatory condition that affects oral tissue, resulting from dysbiosis and maintaining a low systemic inflammatory response. P. gingivalis is a flagship bacterium in oral dysbiosis and periodontal disease. Previous studies have linked PD with a higher risk of gastric cancer (GC). The systemic inflammatory state sustained by PD also causes an immunosuppressive condition led by the activation of immune checkpoints, provoking T cell exhaustion and cancer progression.