Differential incretin effects of GIP and GLP-1 on gastric emptying, appetite, and insulin-glucose homeostasis.
NEUROGASTROENTEROLOGY AND MOTILITY(2010)
摘要
The incretin effect of GIP and GLP-1 differs as GLP-1 exerts a strong glucoregulatory incretin through inhibition of gastric emptying, which GIP does not. Thus, GLP-1 as incretin mimetic may offer unique benefits in terms of weight loss in treatment of type 2 diabetes.
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关键词
appetite,gastrointestinal hormones,glucagon-like peptide,glucose metabolism,insulin signaling
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