Corrigendum: Methylation of FKBP5 and SLC6A4 in Relation to Treatment Response to Mindfulness Based Stress Reduction for Posttraumatic Stress Disorder (Front. Psychiatry, (2018), 9, (418), 10.3389/fpsyt.2018.00418)

There was a significant time x responder group interaction for methylation in FKBP5 intron 7 bin2 [F(1, 19) = 7.492, p = 0.013, Bonferroni adjusted p = 0.052; Figure 4 and Supplemental Table 2] whereby responders had an increase in methylation and non-responders had a decrease in methylation from before to after treatment in this region.Discussion>FKBP5>sentence #1: Analyses of FKBP5 revealed increases in intron methylation after treatment in responders while non-responders had decreases in methylation within a specific FKBP5 CpG site of bin 2.Discussion>FKBP5>Paragraph #2>sentence #4: Additionally, consistent with our findings is that despite examining a different regulator region of FKBP5 than our study (exon 1 promoter vs. intron 7 GRE in our study) both of these investigations showed that changes in methylation were related to better symptom response with corresponding measures of increased gene expression identified in the study of PTSD response to exposure therapy (24).Collectively our findings as well as those of others are consistent with the hypothesis that non-pharmacologic interventions may facilitate stress reduction through the regulation of FKBP5 to feedback on glucocorticoid hyperactivity to reduce stress.