Progressive Development of Cefiderocol Resistance in Escherichia coli During Therapy Is Associated with Increased blaNDM-5 Copy Number and Gene Expression.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America（2021）
Abstract
Our patient's case suggests that increased copy numbers of bla NDM genes through translocation events is used by Enterobacterales to evade cefiderocol-mediated cell death. The frequency of increased NDM expression in contributing to cefiderocol resistance needs investigation.
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Key words
Escherichia coli,NDM,antimicrobial resistance,cefiderocol
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