Prognostic Factors and Outcomes in Patients with Guillain-Barre Syndrome Requiring Invasive Mechanical Ventilation

Objective: To determine clinical and electrophysiological prognostic factors for invasive mechanical ventilation (IMV) in patients with GBS. Background: Almost a third of patients with Guillain-Barre Syndrome (GBS) require mechanical ventilation, increasing mortality by 15–30% and proving poor functional outcomes. Design/Methods: A cross-sectional study was carried out in a referral center in Mexico City, from January 2015 to December 2019. Baseline demographics, MRC, Hughes, EGRIS, dysautonomia and nerve conduction studies were performed in GBS patients requiring IMV. A multivariate analysis for IMV and a survival analysis for independent walk in prolonged-IMV (>14 days) were performed. Results: Forty-nine (32%) out of 153 GBS patients required IMV. Statistically significant prognostic factors for IMV were deltoid muscle strength ≤2 [OR 7.1 (1.6–31.1)], EGRIS [OR 2.5 (1.3–4.6)] and autonomic dysfunction [OR 6.6 (2.0–22.0)]. The prevalence of electrodecrement Conclusions: We provide new specific clinical (deltoid muscle strength and autonomic dysfunction) and electrophysiological variables to discriminate GBS patients that will require IMV. Disclosure: Dr. Jorge De Sarachaga has nothing to disclose. Esther Perez Valdez has nothing to disclose. Maria Eugenia Briseno Godinez has nothing to disclose. Dr. May Mas has nothing to disclose. Esther Perez Valdez has nothing to disclose. Dr. Bazan has nothing to disclose. Dr. Galnares-Olalde has nothing to disclose. Elizabeth Leon has nothing to disclose. Dr. Vargas has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Sanofi. Dr. Vargas has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for CSL Berhing.