Inhibition of CB1 receptor alleviates electroconvulsive shock-induced memory impairment by regulating hippocampal synaptic plasticity in depressive rats

Jian Yu,Li Ren,Su Min,Feng Lv,Jie Luo,Ping Li,Yuxi Zhang

Psychiatry Research（2021）

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摘要

•Endocannabinoid system activates in hippocampus after ECS.•ECS induce spatial learning and memory impaired, reversed by CB1R antagonist.•ECS induce synaptic plasticity dysfunction, restored by inhibiting CB1R.•CB1R antagonist dose not impact the antidepressant effect of ECS.

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关键词

Endocannabinoid system,Learning,Am251,2-arachidonoylglycerol

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