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De‐escalation of dual antiplatelet therapy for patients with acute coronary syndrome after percutaneous coronary intervention: a network meta‐analysis of randomised controlled trials

Ovidio De Filippo,Francesco Piroli,Francesco Bruno,Pier Paolo Bocchino,Andrea Saglietto,Luca Franchin,Filippo Angelini,Guglielmo Gallone,Samer Alabed,Mauro Gasparini,Mahmood Ahmad,Gaetano M. De Ferrari,Fabrizio D'Ascenzo

Cochrane Database of Systematic Reviews（2021）

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Abstract
Objectives This is a protocol for a Cochrane Review (intervention). The objectives are as follows: The objective of this review is to evaluate the available evidence in order to identify an optimal de‐escalation strategy in terms of duration and type of therapy for patients with ACS treated with PCI. We will perform a NMA to appraise the safest and most efficacious combination of type and length of DAPT de‐escalation.
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Key words
dual antiplatelet therapy,percutaneous coronary intervention,acute coronary syndrome,trials,de-escalation,meta-analysis
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