Xanthone glucoside 2-β-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one binds to the ATP-binding pocket of glycogen synthase kinase 3β and inhibits its activity: implications in prostate cancer and associated cardiovascular disease risk

Irengbam Rocky Mangangcha, Raj Kumar Brojen Singh,Djamel Lebeche,Shakir Ali

Journal of Biomolecular Structure and Dynamics（2021）

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摘要

Glycogen synthase kinase 3 (GSK3) is a serine/threonine kinase which in the presence of ATP in its ATP-binding pocket transfers a phosphate to a primed substrate. GSK3β is an isoform of GSK3 which ...

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glycogen synthase kinase 3β,glucoside,prostate cancer,d-glucopyranosyl,h-xanthen,atp-binding

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