Subcutaneous Connective Tissue Reactions to New Calcium Silicate Cements: An Animal Study

The aim of this study was to determine the subcutaneous connective tissue reactions to Medcem MTA and Medcem Pure Portland Cement. Medcem MTA, Medcem Pure Portland Cement and ProRoot MTA were placed in polyethylene tubes and implanted into the dorsal connective tissue of Sprague Dawley rats. The presence of inflammation, edema, necrosis, dystrophic calcification, and thickness of fibrous capsule formation was recorded by histological examination 7, 30, and 60 days after the implantation procedure. Inflammation scores were defined as follows: 0 = no or few inflammatory cells, no reaction, 1 =