Multi-omics data reveals the disturbance of glycerophospholipid metabolism caused by disordered gut microbiota in depressed mice

•Three important ”metabolite type-bacterial genus” correlated pairs were identified.•Peripheral and central GP metabolism was disordered in depressed mice.•Four differential NEs from tryptophan pathway in hippocampus were found.•“Firmicutes-SCFAs-GP metabolism-Tryptophan pathway” was possible way in gut-brain.