Streptozotosin ile Diyabet Oluşturulan Ratlarda Beyaz Dut Ekstraktının Performans, Antienflamatuar ve Serum Antioksidan Parametreleri Üzerine Etkisi

This study was conducted to investigate the effect of the white mulberry extract on histopathology, anti-inflammatory properties of liver tissue, blood serum antioxidant parameters and performance parameters of diabetes-induced rats with streptozotocin.Experimental groups consist of 24 animals which were divided into four groups; control group (C, n: 5), streptozotocin applied group 1 (DG 1, n: 6), mulberry extract applied group 2 (DG 2, n: 7), streptozotocin and mulberry extract experimental group 3 (DG 3, n:6), totally 24 animals were used.Although vascular congestion in the liver tissue was detected 2 animals in C and DG 2 groups and 1 animal in DG 3 group, vascular congestion was detected in all animals in DG 1 group.(P <0.05).Inflammatory findings of liver tissue were not seen in C, whereas it was mild in 2 animals in DG 2 and it was seen in all animals in the group of DG 1. Degeneration findings in liver tissue were not seen in C, but it was detected in 1 animal of DG 2 and all animals in DG 1 (P <0.01).There was no statistical difference between the ceruloplasmin levels of the groups (P> 0.05).Live weight gain in control group 150,03 g., DG 2 114.43 g. (P <0,01).1.33 g. live weight gain and weight loss in DG 3 (P> 0.05).In conclusion, mulberry extract applied to rats significantly reduced vascular congestion, inflammation and degeneration findings in liver tissue and it can be said that mulberry extract has antiinflammatory effect.