A Nanotechnological Approach for Enhancing the Topical Drug Delivery by Newly Developed Liquid Crystal Formulations

Transdermal drug administration is a great substitute to oral medication administration. Inadequate penetration of active pharmaceuticals via the skin, on the other hand, is a common phenomenon. As a result, we investigated the ability of liquid crystal (LC) topical formulations to improve skin penetration in the current study. LC-forming lipids are a significant class of biocompatible amphiphiles with applications in cosmetic, dietary, and medicinal technologies. Just a few experiments have looked into how the concentration of LC-forming lipids affects the ability of drugs to reach the skin following topical application. We initially prepared LC formulations of p-aminobenzoic acid (PABA) as a hydrophilic drug mode (The homogeneity and viscosity of the prepared formulations is determined). Additionally, we used a Zetasizer to determine the zeta potential and particle size of LC formulations. The dialysis procedure was used to determine the liberation of drugs from LC formulations. In-vitro skin penetration tests were conducted to decide if LC formulations could increase skin penetration and concentration. By understanding the influence of the LC-forming lipid concentration used in the LC preparation, researchers might establish LC formulation methods that increase drug skin penetration.