Abstract 14368: Valproic Acid Activates Irg1-Itaconate and Improve Donor Heart Function After Extended Storage Time

Ienglam Lei,Wei Huang,Richard M. Mortensen,Zhong Wang,Eugene Chen,Paul C. Tang

Circulation（2021）

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摘要

Background: Cold ischemic storage and subsequent reperfusion injury contributes to the primary graft dysfunction after heart transplantation. Valproic acid (VPA) has been shown to reduce myocardial...

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