The Effects of High-Versus Low-Intensity Resistance Exercise on Acute Hyperglycemia in Young Healthy Males: 1397 Board #159 May 30 10:30 AM - 12:00 PM

ACSM 2019 THE EFFECTS OF HIGH- VERSUS LOW- INTENSITY RESISTANCE EXERCISE ON ACUTE HYPERGLYCEMIA IN YOUNG HEALTHY MALES Luis E. Segura, Brandon Beimborn, Shayan Emamjomeh, Josh A. Cotter, PhD, Evan E. Schick, PhD Nearly one-third of Americans older than 18 years of age are pre-diabetic, yet much remains to be understood about this condition. Regular exercise can help control prolonged hyperglycemia, a flagship symptom of type 2 diabetes, however, the nature in which exercise can alleviate periods of acute hyperglycemia, a common symptom of pre-diabetes, is unclear. PURPOSE: The purpose of this study was to examine the effect of high-intensity (HI) versus low-intensity (LO) resistance exercise (RE) on acute hyperglycemia in resistance-trained males. METHODS: Thirteen recreationally trained males (age, 23.43 ± 2.18 yrs.; height, 175.16 ± 10.44 cm; mass, 77.02 ± 8.91 kg) completed three randomized testing sessions separated by 96 hours: 1) no exercise control (CON), 2) HI (5x4, 90% 1-RM), and 3) LO (3x14, 65% 1-RM). Following overnight fast, all three-testing session commenced with oral ingestion of a high glucose drink (2 g glucose/kg body weight). HI and LO RE protocols began 30 mins post-glucose ingestion. Capillary blood samples obtained via finger stick occurred immediately pre- and 30, 60, 90 and 120-mins post-glucose ingestion. RESULTS: A two-way ANOVA revealed a significant (p<0.015) time main effect for plasma glucose and insulins concentrations throughout the 120 min testing duration, however neither glucose or insulin differed between conditions at any of the individual time points. One-way ANOVA showed that total glucose response in the HI condition, as assessed by AUC, was significantly greater (p<0.012) than in both CON and LO. Strong negative correlations existed between total body mass and lean body mass (r= -0.78) as well as lean body mass and LO glucose AUC (r= -0.78). CONCLUSIONS: High intensity resistance exercise may exacerbate acute episodes of hyperglycemia, thus combining high intensity with lower intensity resistance exercise may optimally manage skeletal muscle health and glycemic control.