Влияние полиморфизма 1846g>a гена CYP2D6 на показатели эффективности и безопасности лексотана у пациентов с тревожными расстройствами и алкогольной зависимостью

Ф. Х. Закиров,М. С. Застрожин, В В Смирнов,А. Е. Петухов,Е. П. Панкратенко,А. К. Застрожина,Е. А. Гришина,К. А. Рыжикова,И. В. Буре,В. Ю. Скрябин,В. В. Шипицын,Е. А. Брюн,Д. А. Сычев, Т. М. Рожнова

Nauchno-prakticheskii zhurnal «Medicinskaia genetika»（2020）

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Abstract

Аnxiety disorders are considered a serious problem of psychiatry being comorbid with other states. In this context investigation of factors responsible for unequal drug efficiency and safety in different patients is needed. Among these factors, genetics is considered to be one of the most important. This study assessed the role of CYP2D6 gene polymorphism 1846G>A in Lexotan efficiency and safety in patients with anxiety disorders comorbid with alcoholism.

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Key words

cyp2d6 gene polymorphism 1846g>a,anxiety disorders,lexotan efficiency,alcoholism

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