WITHDRAWN: Mechanisms and potential therapeutic targets for intracerebral hemorrhage

Abstract In this review, we summarize recent research related to intracerebral hemorrhage (ICH) and offer new insight into its pathomechanisms. These underlying pathomechanisms of ICH provide clues for development of novel drugs or drug target screening. Specifically, recent research has provided evidence that iron chelators, lipid peroxidation/ferroptosis inhibitors, antagonists or agonists of prostaglandin E2 receptors (EP1/3 or EP2), and nonsteroidal anti-inflammatory drugs protect against ICH-induced brain edema and secondary brain tissue damage, and inhibit the toxicity of related tissue damage products. This review will provide a theoretical basis for testing new compounds that may have potential for future clinical trials.