Prevalence of Igg Antibodies Against SARS-CoV-2 Among the General Population and Healthcare Workers in India, June–July 2021

Manoj V Murhekar,Tarun Bhatnagar, Thangaraj Jwv, Saravanakumar,Muthusamy Santhosh Kumar,Sriram Selvaraju,Kirankumar Rade, Kumar Cg,R. Sabarinathan,Alka Turuk,Nivethitha N Krishnan,Aby Robinson, Srinivasan N,Smita Asthana,Rakesh Balachandar,Sampada Dipak Bangar,Avi Kumar Bansal,Jyothi Bhat, Chopra,Dasarathi Das,Alok Kumar Deb,Kangjam Rekha Devi,Gaurav Raj Dwivedi,Khan Sms,Avula Laxmaiah,Major Madhukar,Amarendra Mahapatra,Chethana Rangaraju,Jyotirmayee Turuk,Sumit Yadav,P. K. Anand,Rushikesh Andhalkar,Nimmathota Arlappa, Bashir K,Dinesh Kumar Baradwaj,Pravin Bharti,Debdutta Bhattacharya,Behera Sp,Ashrafjit S. Chahal,Debjit Chakraborty,Anshuman Chaudhury,Hirawati Deval,Sarang Dhatrak, Dhikav, Dayal R,Prathiksha Giridharan,Inaamul Haq,Jagjeevan B, Jain A,Arshad Kalliath,Srikanta Kanungo, Karunakaran T,Jaya Singh Kshatri,Niraj Kumar, Kumar,Virendra Kumar, Lakshmi Ggjn, Mehta G,Anindya Mitra, K. Nagbhushanam, A.R. Nirmala,Subrat Kumar Palo, Pandey Ak,Ganta Venkata Prasad, Pucha Uk,Mariya Amin Qurieshi, Sabaharwal,Seema Sahay,Ramesh Kumar Sangwan, Saxena R,Krithikaa Sekar,Vijay K. Shukla,Himmat Singh,Pushpendra Singh,Prashant Singh,Rajeev K. Singh, Thakor M,Dantuluri Sheethal Varma,Ankit Viramgami, Menon Pa,Rajiv Yadav,Manjula Singh,Amit Chakrabarti,Aparup Das,Shanta Dutta,Rajni Kant,A.M. Khan,Kanwar Narain,Somashekar Narasimhaiah,Chandrasekaran Padmapriyadarshini,Krishna Pandey,Sanghamitra Pati,Hemalatha Rajkumar,Ramesh T,Sharma Ak,Y.K. Sharma,Shalini Singh,Samiran Panda,D C S Reddy,Balram Bhargava

Social Science Research Network(2021)

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摘要
Background: India witnessed a severe second wave of COVID-19 during March and June 2021. We did the fourth nationwide serosurvey to estimate prevalence of SARS-CoV-2 antibodies in the general population aged >=6 years and health care workers (HCWs).   Methods: We did a cross-sectional study between 14 June and 6 July 2021 in 700 clusters in the same 70 districts across 21 states/Union Territory. From each district, a minimum of 400 individuals aged >=6 years from general population and 100 HCWs from the district public health facilities were included. The serum samples were tested for the presence of IgG antibodies against S1-RBD and nucleocapsid protein of SARS-CoV-2 using chemiluminescence immunoassay. We estimated the weighted and test adjusted seroprevalence of IgG antibodies against S1-RBD and/or nucleocapsid protein along with 95% CI.  Findings: Of the 28,975 sera tested, the weighted and test adjusted prevalence of IgG antibodies against S1-RBD and/or nucleocapsid protein among the general population aged >=6 years was 67.6% (95% CI: 66.4 – 68.7). The seroprevalence increased with age and was not different in rural and urban areas. Compared to unvaccinated adults (62.3%, 95% CI: 60.9 – 63.7), seroprevalence was significantly higher among individuals who received one (81.0%, 95% CI: 79.6 - 82.3) and two doses (89.8%, 95% CI: 88.4 - 91.1). The seroprevalence of IgG antibodies among 7,252 health care workers was 85.2% (95% CI: 83.5 - 86.7).  Interpretation: Nearly one third of the population is still seronegative. It is necessary to accelerate the coverage of COVID-19 vaccination among adults and continue adherence to non-pharmaceutical interventions. Funding: Indian Council of Medical Research. Declaration of Interest: None to declare. Ethical Approval: The Institutional Human Ethics Committee of the ICMR National Institute of Epidemiology, Chennai approved the study protocol.
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antibodies,igg,healthcare workers,sars-cov
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