Tissue Expression of HSP27 in Prostate Cancer Is Correlated with the Aggressivity of Cancer in the Algerien Population
Medical Technologies Journal(2020)
摘要
Background: Prostate Cancer (CaP) is the second most common cancer in men and a major public health problem. Clinical outcomes at diagnosis are heterogeneous and difficult to predict, so predictive and diagnostic markers are needed. Heat shock proteins (HSPs) such as HSP27 are highly regulated in several malignant tumors. Basal HSP27 levels in most human tissues are low compared to high levels in tumors.
Methods: In this work, we evaluated, in subjects with CaP, the levels of expression of the HSP27 antigen in tumor tissues and its association with tumor aggressiveness. The Immunohistochemical (IHC) method was used to determine the expression of HSP27 in 58 prostate cancer tissues and 4 prostate hyperplasia (BPH).
Results: Tissue levels of HSP27 were significantly higher in patients with CaP than in BPH (QSM = 153.43±0; P 7), we found a very significant increase in HSP27 protein (QSM = 169.73±84.26; P<0.0001) compared to non-aggressive cancer (Gleason score ≤ 7) (QSM = 123.92± 91.36; P<0.001).
Conclusion: Overexpression of HSP27 in the tissues of patients with CaP compared to patients with BPH may be of diagnostic and/or prognostic interest and maybe a therapeutic target in patients with prostate cancer.
更多查看译文
关键词
prostate cancer,hsp27,tissue expression
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要