Dissecting the Protective Effect of Phosphodiesterase 3A Hyperactivity on the Heart Using Single Nuclei Sequencing and Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Michael B. Mucke,Tamara Pallien,Philip Dierks,Ryan Walker-Gray,Anastasiia Sholokh,Duncan C. Miller,Sebastian Diecke,Norbert Hubner,Enno Klussmann

CIRCULATION（2021）

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摘要

Mutations causing hyperactivity of phosphodiesterase 3A (PDE3A) lead to autosomal dominant hypertension with brachydactyly type E. Affected patients suffer from profoundly increased blood pressure ...

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