Proteínas importantes para la invasión de Babesia bovis a las células huésped

Introduction. Bovine babesiosis is caused by Apicomplexas parasites of the genus Babesia, Babesia bovis being the species associated with the most serious clinical conditions of the disease. B. bovis invasion into the bovine erythrocytes involves the interaction between the parasites merozoites molecules with host cell receptors. Therefore, knowing the proteins involved in the invasion process will enable understanding the parasite biology. Objective. To describe the important molecules involved in the B. bovis invasion process to bovine erythrocytes. Methodology. A search was made on NCBI, Medline, LILACS and SciELO databases using keywords as “Babesia bovis AND invasion process”, “MSA-1”, “RON2”, “AMA-1”, “moving junction”, “B. bovis AND Vaccine candidates”. 61 studies written in English describing the study for proteins that take place during invasion process which have been published until mayo were completely revised. Results. Given that the bovine erythrocyte invasion process is key for the pathogenesis of bovine babesiosis, a review was made where 3 proteins were found to be associated to the recognition and invasion processes of target cells: MSA-1, AMA-1 and RON2. However, the details at molecular level for the inter an intramolecular interaction have not yet been fully elucidated. Conclusions. Study the molecules involved in host-parasite interactions will allow understanding how the B. bovis invasion process to erythrocytes occurs and evaluating their future utility as a component of an effective control strategy for this parasitosis.