AntiTNF α: Risk Factor of Major Complications Following Ileocolic Resection for Crohn's Disease

Introduction: The aim of this study was to determine the risk factors of complications in the era of anti-tumor necrosis factor. Methods: This was a single-center retrospective study covering the period 1999 to 2015 of patients who underwent a first ileocolic resection for Crohn's disease. We evaluated the impact of preoperative characteristics and operative data on serious complications within 90 days after surgery. Results: 146 patients were included. Post-operative morbidity was 43.8 % with 21 serious complications (14.4%). A univariate analysis, anti TNF in the 3 months before surgery (p= 0.0007), anti TNF and corticosteroid combination (p = 0.006), and operating time upper than 150 minutes (p= 0.01),were associated with the occurrence of a serious complication. In multivariate analysis, anti TNF (OR = 4.21; 95% CI 1.23 to 16.87; p= 0.02) and conversion (OR = 7.95; 95% CI = 1,68- 44.89; p= 0.009) were risk factors of serious complications. Conclusion: The use of anti-TNF within 3 months before surgery and conversion during laparoscopy are risk factors of serious complications after ileocolic resection for Crohn's disease.