Positive Effect of Chaiqin Wendan Decoction on Anxiety and Depression Model Rats

Abstract Objectives: To investigate the effect of Chaiqin Wendan Decoction (CWD) and mechanisms for anxiety and depression-like behavior in rats. Methods: We divide SD male rats into four groups randomly (blank group, model group, diazepam group and Chinese medicine group). The anesity and depression model rats were induced by chronic unpredictable emotional stress. Chinese medicine group and diazepam group were given CWD and diazepam respectively. The model group and the blank group were given the same amount of normal saline per day. The general state of the rats was recorded, and an open field trial and operation of the Morris water maze test were performed.the concentration of 5-HT was measured. Results: Compared with the model group, the body weight, horizontal movement distance score, number of upright, and target quadrant percentage of the rats in the Chinese medicine group increased significantly (P <0.05), and the latency decreased significantly (p <0.05). The concentration of 5-HT in the Chinese medicine group and diazepam group was significantly decreased by ELISA kit (P<0.05).Conclusion:WD can significantly promote the learning and cognitive ability of rats with anxiety and depression. Its mechanism of action may be closely related to the ability of CWD to reduce 5-HT concentration.