Changes In Aortic Root Size Over Time In Patients with 22Q11.2 Deletion Syndrome

Background: Aortic root dilation (ARD) has been reported in patients with 22q11.2 deletion syndrome (22q11.2DS) with and without congenital heart defects (CHDs). The long-term implications of ARD in 22q11.2DS are unknown and thus the timing and necessity of long-term follow up is undefined. The aim of this study is to better understand the prevalence, longitudinal course and clinical risk factors for ARD in patients with 22q11.2DS without major CHDs. Methods: Patients less than 25 years with 22q11.2DS were identified from the electronic medical record and 22q and You Center …