Abstract 13192: Local Delivery of Thrombin Inhibiting Nanoparticles Preserves Cardiac Function and Modulates NLRP3 Inflammasome Processes in Acute Myocardial Infarction

Ian Vargas,Qingyu Zhou,Ryan Grabau,Junjie Chen,Carla J. Weinheimer,Attila Kovács, William Dominguez-Viqueira,Hua Pan,Samuel A. Wickline

Circulation（2021）

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摘要

Introduction: The role of thrombin in acute myocardial infarction (AMI) has been well described, with recent attention having turned to its effect on NLRP3 inflammasome activation and the role that...

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