Pengaruh ekstrak daun binahong (Anredera cordifolia ) terhadap pemulihan siklus estrus mencit (Mus musculus)

This study aimed to determine the effect of binahong ( Anredera cordifolia ) leaf extract on the recovery of the estrous cycle of mice ( Mus musculus ) which has been induced for the extension of the estrous cycle using angsana ( Pterocarpus indicus ) bark extract. In this study vaginal smear was performed daily at 10.00 WIB to determine the phase of the estrous cycle for 26 days. Mice were divided into 5 groups, each with 6 replicates. The treatments were T1 (positive control), T2 (negative control), T3 (0.8 mg/head/day), T4 (2.4 mg/head/day) and T5 (4 mg/head/day). The data obtained were processed using Analysis of Variance (ANOVA) and followed by the Duncan's New Multiple Range Test (DNMRT) at a 95% level of significance.  The results showed that the angsana ( Pterocarpus indicus ) bark extract adminsitration (T2) lengthen (p 0.05) compared to T1 group. However, the higher dose of binahong ( Anredera cordifolia ) leaf extract (T5) revealed the length of estrous cycle was not significantly different (p >0.05) compared to T2 group. It can be concluded that the administration of binahong leaf extract was able to recover the normal estrous cycle of mice.