Efeito do exercício físico e da suplementação com L-arginina em marcadores bioquímicos, antropométricos e de força em mulheres com Hipotireoidismo

Hypothyroidism is characterized by a dysfunction of the thyroid gland that has a high production of thyroid stimulating hormone (TSH) and fails to produce its hormones thyroxine (T4) and triiodothyronine (T3) correctly. Frequent in female populations, it is related to secondary dyslipidemias, endothelial dysfunction, and the reduction of the bioavailability of nitric oxide (NO). Objective: This study evaluated the effect of physical exercise and L-arginine supplementation on the levels of NO, lipid profile, anthropometric and physical data in 16 hypothyroid women residing in the city of Sarandi-RS. Materials and Methods: Characterized by a randomized clinical trial by intervention, divided into four groups. G1: exercise and supplementation; G2: exercise; G3: supplementation with L-arginine and G4: control. To evaluate the physical abilities of the volunteers, anthropometric data (weight, height, waist and hip measurements, skinfolds), 1RM strength tests, and VO2 max treadmill test were analyzed. Blood tests were performed on CT, HDL, LDL, TG, TSH, T3, T4 and NO. Results: The results obtained were significant for the reduction of% G and increase of lean mass for the G1 and G3 groups, as well as an increase of 1RM in G1 and G2. Other important results observed were the significant increase of NO to G1, and from T3 to G2. Conclusion: L-arginine supplementation may be beneficial to the studied population, and may improve quality of life, reducing CT and increasing bioavailability of NO, as well as physical exercise may be beneficial to increase T3