Coronary Disease Association With ADAMTS7 is Due to Protease Activity: Implications for Therapeutic Development

Taiji Mizoguchi,Bryan T. MacDonald,Bidur Bhandary, Nicholas R. Popp, Dylan Laprise,Alessandro Arduini,Daniel Lai,Qiuyu M. Zhu,Yi Xing,Virendar K. Kaushik,Sekar Kathiresan,Patrick T. Ellinor

Circulation（2021）

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摘要

Background: Despite contemporary therapy, coronary artery disease (CAD) remains a leading cause of mortality. Genetic variants at ADAMTS7 have been associated with CAD and the loss of ADAMTS7 is pr...

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