Dual fluorescence guidance improves extent of brain tumor removal surgery

Haini Zhang,Suman B. Mondal,Dorota Grabowska,Matt Mixdorf,Gail Sudlow,Christine M. O'Brien,Julie L. Prior,Kexian Liang,Rui Tang,Samuel Achilefu

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XIII（2021）

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Abstract

LS301 is a promising NIR fluorescence probe for targeting brain glioma cancer. The co-localization of LS31 and 5-ALA induced PpIX in vitro and in vivo enables LS301 to guide PpIX fluorescence image surgery. Moreover, LS301 showed no negative impact on 5-ALA-PpIX PDT outcome in brain glioma cells and mouse tumor model. Therefore, the implementation of LS301 and PpIX has potential to improve tumor resection surgery and PDT treatment for better tumor outcomes.

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Key words

dual fluorescence guidance,brain tumor removal surgery

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