Validación de un algoritmo de obtención de biomarcadores de imágenes dinámicas de perfusión en tomografía computarizada

Several physiologic characteristics related with permeability of tissues can be obtained from the analysis of dynamic images of the perfusion of contrast agent in CT images. Since there are no reference materials to calibrate both acquisition and processing tools, analysing digital reference objects is necessary in order to test them. The accuracy and precision of a non-linear fitting algorithm for the analysis of perfusion CT images using the extended Tofts model are reported in this text. Tests are performed using synthetic images where the parameters of the model are known.