Multimodal Monitoring of Human Brain Organoids Implanted in Mice Using Transparent Microelectrodes

Martin Thunemann,Madison Wilson,Francesca Puppo,Donald P. Pizzo, Hannah Rickner,Emma Bortz,Abed AlFatah Mansour,Benjamin Wolozin,Xue Han,Fred H. Gage,Alysson R. Muotri,Duygu Kuzum,Anna Devor

Brain（2021）

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摘要

We present an in vivo platform merging stem cell technology, two-photon imaging, and electrophysiology with transparent graphene microelectrodes for longitudinal interrogation of human brain organoids implanted in the cortex of immunodeficient mice.

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