Experimental Autoimmune Encephalomyelitis: In Vivo Induction of Regulatory T Cells Via CTLA-4 Signaling Peptide to Control Autoimmune Encephalomyelitis and Prevent Disease Relapse (Adv. Sci. 14/2021)

In article number 2004973, Je-Min Choi and co-workers develop a synthetic peptide dNP2-ctCTLA-4 that regulates experimental autoimmune encephalomyelitis progression and relapse in the longterm by inducing Foxp3+ Treg cells in vivo. This peptide induces Treg cells in human peripheral blood mononuclear cells from multiple sclerosis (MS) patients and in a humanized mouse model, demonstrating that it would be a novel therapeutic agent for MS.