Sustained response after remdesivir and convalescent plasma therapy in a B-cell depleted patient with protracted COVID-19.

Jakob Heinrich Malsy,Luzia Veletzky,Janna Heide,Annette Hennigs,Ines Gil-Ibanez,Alexander Stein,Marc Lütgehetmann,Ulrich Rosien,Dorothea Jasper,Sven Peine,Jens Hiller,Friedrich Haag,Stefan Schmiedel,Samuel Huber, Sabine Jordan,Marylyn M. Addo,Julian Schulze zur Wiesch

Clinical Infectious Diseases（2020）

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摘要

We provide detailed clinical, virological and immunological data of a B-cell depleted patient treated with obinutuzumab for follicular lymphoma with protracted COVID-19 and viremia. A sustained response was achieved after two courses of remdesivir and subsequent convalescent plasma therapy. Immunocompromised patients might require combined and prolonged antiviral treatment regimens.

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关键词

protracted coronavirus disease,convalescent plasma therapy,remdesivir,sustained response,b-cell

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