Intercalation of Ciprofloxacin in Naturally Occurring Smectite from Bana: Potentiality as Drug Delivery System and Antimicrobial Effects on Escherichia coli and Staphylococcus aureus
Journal of Materials Science and Chemical Engineering(2021)
摘要
Ciprofloxacin (CFX) was loaded on Bana clay (Cameroon) and CFX loadedclays
have been evaluated as drug delivery system. Raw clays and CFX loaded
compounds have been characterized by some physico-chemicals methods. In
vitro release studies have been done in gastric and phosphate buffer experimental
mediums; bacteriological studies have been made up on Escherichia coli
and Staphylococcus aureus. X-ray diffractometry patterns of loaded compounds
show a basal spacing increasing due to CFX intercalation. On Fourier-Transformed
Infrared spectrometry spectra, appearance of CFX characteristic bands
and shifting of certain bands already presents on clay confirmed CFX intercalation.
After 96 h of CFX released from release mediums, prolonged and continue
profiles have been observed. Diffusion tests displayed an inhibition radius
of ~2 cm on gelose seeded with Escherichia coli and Staphylococcus aureus
due to CFX. The overall results show a modified release of ciprofloxacin
with an effective antibacterial activity, giving the way for a new ciprofloxacin
drug delivery system using Bana clay as carrier.
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关键词
ciprofloxacin,antimicrobial effects,smectite,drug delivery system
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