Improvement of snake antisera production using new innovative adjuvants (w/o formulation)

Undoubtedly, the snake anti-venom is a medication made up of antibodies used to treat itsbites by venomous snakes. Repeated administration of snake venoms from Spitting cobra, ingradual sub-lethal doses into horses has been reported to cause various ill health conditions torecipient animals beside loss in the antibody titer in the plasma harvested from immunizedhorses. It could accordingly, propose some amendment in the immunization schedule usingdifferent adjuvants to choose the best one giving the maximal amount of antibody beside itsmax safety measures. Montanide ISA is an alternative to CFA for hyper-activation of immuneresponse in rabbits beside it is considered as adjuvant with high safety margin.