Оценка антиметастатической активности экстрактов Filipendula ulmaria в зависимости от экстрагента

Three extracts were obtained from the aerial parts of meadowsweet ( Filipendula ulmaria (L.) Maxim.) using water, 40% ethanol, and 70% ethanol as extractants. Comparative assessment of their effect on the development of Lewis lung carcinoma (LLC) in C57Bl/6 line mice showed that, in isolated introduction, development of the metastatic process was inhibited by the extracts prepared in water and 70% ethanol, without influence on the growth of the tumor node. A comparative assessment of the effect of extracts on the antitumor effect of cyclophosphane (CPh) on the primary tumor node showed no changes in effectiveness of the cytostatic agent. When included in the treatment regimen of mice using extracts at a dose of 25 and 50 μg/kg, a significant increase in the antimetastatic action of CPh was detected under the influence of aqueous extract with metastasis inhibition index IMI = 75 and 98%, respectively, and with 70% ethanol extract (IMI = 95 and 96%). The effect of 40% ethanol extract on development of the tumor process in mice with LLC and the effectiveness of CPh therapy were not found.