Clinical evaluation and comparison of platelet-rich fibrin and injectable platelet-rich fibrin (sticky bone) in the treatment of intrabony defects

Introduction: Periodontal regeneration aims to regenerate the lost periodontium, and platelet concentrates are frequently used in the medical fields to improve the healing and promote tissue regeneration. Objective: The aim of the study was to evaluate the efficacy of injectable platelet-rich fibrin (i-PRF) (sticky bone) in comparison to platelet-rich fibrin (PRF) in the treatment of intrabony defects. Materials and Methods: A total of 54 sites treated were divided into three groups (Group I – open flap debridement [OFD alone], Group II – OFD with i-PRF [sticky bone], and Group III – OFD with PRF) in moderate-to-severe periodontitis. The clinical parameters assessed were plaque index, gingival index, probing pocket depth (PPD), relative attachment level, and defect depth reduction at baseline, 3, 6 and 9 months. Results: Nine months postoperatively, a significant improvement in clinical and radiographic parameters was observed from baseline in all three groups. However, Group II and Group III showed better results in all the parameters compared to Group I. Nine months postoperatively, the defect depth reduction was: OFD - 41.59%, i-PRF - 72.75%. and PRF - 62.11%. Conclusion: PC (i-PRF [sticky bone] and PRF) have shown better clinical and radiographic outcomes than OFD in the treatment of intrabony defects in chronic periodontitis.