Synthesis and biological evaluation of 1,2,4-oxadiazole incorporated 1,2,3-triazole-pyrazole derivatives as anticancer agents

Abstract A library of 1,2,4-oxadiazole incorporated 1,2,3-triazole-pyrazoles (10a-j) were designed, synthesized and tested for their anticancer activities towards human cancer cell lines such as PC3, DU-145 (prostate cancer), A549 (lung cancer) and MCF-7 (breast cancer) by using MTT method with etoposide as standard drug. Among them, compound 10b showed most promising anticancer activity against PC3, A549, MCF-7, and DU-145 cell lines with IC50 values of 0.01±0.008 µM; 0.45±0.023 µM; 0.081±0.0012 µM and 1.77±0.33 µM.