Early response dynamics predict treatment failure in patients with recurrent and/or metastatic head and neck squamous cell carcinoma treated with cetuximab and nivolumab

Daniel J Glazar,Matthew Johnson,Joaquim Farinhas,Conor E Steuer,Nabil F Saba,Marcelo Bonomi,Christine H Chung,Heiko Enderling

Oral Oncology（2022）

引用 8|浏览12

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摘要

•Tumor growth inhibition model accurately reproduces tumor burden dynamics.•Pre-treatment growth rate and time to progression are negatively correlated.•Early treatment response dynamics have potential to predict disease progression.

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关键词

Head and neck cancer,Mathematical model,Predictive model,Forecast,Cetuximab,Nivolumab,Treatment resistance

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