Azepanodipterocarpol is potential candidate for inhibits influenza H1N1 type among other lupane, oleanane, and dammarane A-ring amino-triterpenoids

A series of lupane-, oleanane- and dammarane-based triterpenoids with 3 β -amino, A-ring azepano- and 3,4- seco -fragments has been synthesized and evaluated for antiviral activity against influenza A(H1N1) virus. It was found that azepanodipterocarpol 8 and 3 β -amino-28-oxoallobetulin 11 showed antiviral activity with IC 50 1.1 and 2.6 μg ml −1 , and selectivity index of 19 and 10, respectively.