The combined use of long non-coding RNA HOTAIR and polycomb group protein EZH2 as a prognostic marker of lung adenocarcinoma.

Toshihiko Iizuka,Hiroko Nagano,Kimie Nomura,Miyako Hiramatsu,Noriko Motoi,Mingyon Mun,Yuichi Ishikawa

Cancer treatment and research communications（2022）

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摘要

More accurate prognoses would be possible by simultaneously measuring both genes than measuring either. The high-HOTAIR and high-EZH2 (protein) status, compared to the low-low, is proposed as an independent prognostic marker for stage I cases. Thus, it would serve as a potential biomarker for anti-EZH2 therapy.

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关键词

Biomarker,Epigenetics,LncRNAs,PRC2,Prognosis

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