Efficacy and tolerability of therapies set under pharmacogenetic tools suggestions: A systematic review with meta-analysis about mood disorders

•Meta-analysis shows that PGTs, compared to TAU, appears to be useful tools in setting more effective therapies for major depressive disorder.•No significant results emerged in the metanalysis regarding the comparison of PGT versus TAU in terms of efficacy in the treatment of bipolar disorder.•The review seems to give promising data dealing with the use of PGT to improve tolerability in the treatment of mood disorder.