Local and distant cortical responses to single pulse intracranial stimulation in the human brain are differentially modulated by specific stimulation parameters

•Intracranial single pulse electrical stimulation (SPES) response increases with increased pulse duration near stimulation.•SPES response varies nonlinearly with injected current with an effect of distance from the stimulation site.•SPES near the grey-white boundary has larger local responses, but white matter stimulation induces larger distant responses.•The relationship between SPES location and responses depends on brain region stimulated.